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KMID : 1812720200020010045
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International Journal of Heart Failure
2020 Volume.2 No. 1 p.45 ~ p.54
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The Impact of Body Mass Index on the Prognostic Value of N-Terminal proB-Type Natriuretic Peptide in Patients with Heart Failure: an Analysis from the Korean Heart Failure (KorHF) Registry
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Kim Hack-Lyoung
Kim Myung-A
Oh So-Hee
Choi Dong-Ju
Han Seong-Woo
Jeon Eun-Seok
Cho Myeong-Chan
Kim Jae-Joong
Yoo Byung-Su
Shin Mi-Seung
Kang Seok-Min
Chae Shung-Chull
Ryu Kyu-Hyung
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Abstract
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Background and Objectives: Although an inverse correlation between the level of amino (N)-terminal pro-brain natriuretic peptide (NT-proBNP) and body mass index (BMI) has been reported, the impact of BMI on the prognostic value of NT-proBNP has not been well addressed.
Methods: A total of 1,877 patients (67-year-old and 49.9% females) hospitalized for acute heart failure (HF) with documented NT-proBNP levels at baseline were included. Patients were classified into 2 groups by BMI (nonobese: BMI<23 kg/m2 and overweight or obese: BMI≥23 kg/m2). Clinical events during the follow-up including all-cause mortality and HF readmission were assessed.
Results: During the median follow-up of 828 days (interquartile range, 111?1,514 days), there were 595 cases of total mortality (31.7%), 600 cases of HF readmission (32.0%), and 934 cases of composite events (49.8%). In unadjusted analyses, higher NT-proBNP level was associated with all-cause mortality and composite events (all-cause mortality and HF readmission) in both patients with BMI<23 kg/m2 and those with BMI≥23 kg/m2. In adjusted analyses controlling for potential confounders, however, a higher NT-proBNP level was associated with all-cause mortality and composite events in patients with BMI<23 kg/m2, but not in those with BMI≥23 kg/m2.
Conclusions: The prognostic value of NT-proBNP was more significant in nonobese patients than in overweight and obese patients in this HF population. BMI should be considered when NT-proBNP is used for risk estimation in HF patients.
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KEYWORD
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Body mass index, Heart failure, NT-proBNP, Prognosis, Obesity
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